Case Study: Elevating Programmatic Performance with Health Union’s Amplify+

Unlocking Unrivaled Reach and Engagement in Pharmaceutical Advertising

Published Jul. 29, 2025 | 4 Minute Read

In today’s dynamic healthcare landscape, reaching the right patients and caregivers with impactful messages is paramount for pharmaceutical brands. However, traditional programmatic approaches often fall short, relying on outdated or generic data that can lead to inefficient spending and missed opportunities. At Health Union, we’re transforming this paradigm with Amplify+, our cutting-edge programmatic data solution, designed to deliver unparalleled performance, quality, and precision.

The Health Union Difference: Community-Driven Insights Fueling Active Audiences

For over 15 years, Health Union has cultivated the largest portfolio of condition-specific online communities, fostering authentic connections and providing invaluable support to millions of patients and caregivers. This deep engagement within our owned-and-operated platforms generates a continuous, real-time stream of proprietary zero-party (0P) and first-party (1P) data—all collected with explicit consent and transparency.

Amplify+ harnesses this unique data foundation to activate solution-seeking patients and caregivers at scale. Unlike conventional providers who depend on retrospective 3P claims data, our audiences are built from the real-time engagements of 50 million 1P patient IDs within our vibrant communities. This means we’re reaching individuals actively navigating their health journeys, reflecting their current behaviors, sentiments, and needs.

What sets Amplify+ apart?

  • Privacy-First Data: Our foundation is built on proprietary 0P/1P data, ensuring regulatory compliance and complete transparency.
  • Expanded & Incremental Reach: Our unique data unlocks net-new audiences. Recent tests show up to 76% net-new reach, meaning you’re connecting with individuals inaccessible through traditional data sources.
  • Real-Time Behavioral Insights: Our data is refreshed daily, capturing the most current patient and caregiver actions and triggers, a stark contrast to often-outdated claims data.
  • Direct Caregiver Targeting: We precisely target self-identified caregivers, including pediatric caregivers, moving beyond imprecise household expansion methods.
  • Active, Engaged Audiences: We identify and segment patients and caregivers who are “off the couch”—actively managing their health, seeking solutions, and primed to take action.

The Power of Illuminé: AI-Driven Precision and Continuous Optimization

The secret behind Amplify+’s superior performance lies in our sophisticated, AI-driven data engine: Illuminé. We’ve invested over three years meticulously building and continuously enhancing Illuminé, leading to significant advancements in audience quality.

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Our expert data science team has implemented strategic optimizations that dramatically improve segment construction and drive higher performance for brands, including smarter model building, enhanced quality validation, and refined sampling techniques. 

These enhancements are not just theoretical; they translate into measurable improvements. Since the second quarter of 2024, the V5 release of Amplify+ has driven an astounding 1940% Audience Quality (AQ) improvement, making it Health Union’s most sophisticated audience yet. This continuous optimization ensures that our audiences are not only highly qualified but also remain consistently top-performing.

A Real-World Success Story: Duchenne Muscular Dystrophy (DMD) Brand Exceeds Every KPI

The power of Amplify+ is best demonstrated through real client success. A leading pharmaceutical brand specializing in Duchenne muscular dystrophy (DMD) sought to drive efficient, qualified reach and engagement among this hyper-specific rare disease audience. This was a challenging goal, requiring pinpoint accuracy in targeting.

Health Union’s Solution: We leveraged Amplify+’s differentiated programmatic audiences, meticulously built from 0P/1P engagements within our relevant rare disease communities, to reach and activate these critical DMD audiences.

The Results Were Exceptional: Health Union’s Amplify+ audiences delivered superior, benchmark-beating results against every single KPI:

  • Quality: We achieved a 3.1X improvement above the median competitor performance (8.7x TM vs. 2.8x TM), demonstrating unparalleled audience quality.
  • Efficiency (“Cost Per”): Our campaign was 77% more efficient than the client’s benchmark ($1.85 vs. $8.00), significantly reducing their cost per desired action.
  • Engagement: We drove an incredible 15X increase in engagement above the client’s benchmark (1.49% vs. 0.10%), proving the profound relevance and activeness of our audiences.

This case study unequivocally proves Amplify+’s ability to not only reach the right patients and caregivers but also to efficiently engage them, inspiring action and driving meaningful conversions for even the most challenging, rare disease indications.

Partner with Health Union for Superior Results

At Health Union, we don’t just provide data, we provide solutions. Our unique combination of deeply engaged communities, proprietary 0P/1P data, AI-driven insights from Illuminé, and a steadfast commitment to consumer privacy positions us as an exceptional partner for pharmaceutical advertisers and media agencies. We are confident in our ability to deliver superior reach, quality, and cost-efficiency, proving the unparalleled value of our Amplify+ data solution.

Ready to break through the noise and activate audiences that truly drive results?

Contact us today to explore how Health Union’s Amplify+ can maximize the impact of your programmatic media campaigns and deliver the conversions you need.

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